Changing the way medical conditions are diagnosed...
Whether it's through medical imaging systems or biological markers. Companies in Yokneam are changing the way medical conditions are being diagnosed.
The disposable camera capsules developed in Yokneam by Given Imaging have already spared more than 1.5 million people from having to undergo invasive endoscopic procedures. Patients simply swallow a disposable pill-sized camera that enables their physician to visualize the small bowel, esophagus and colon to monitor and diagnose disorders of the gastrointestinal tract. With over 100 million people diagnosed each year, gastrointestinal (GI) disorders are one of the most common complaints made to physicians worldwide and the gastrointestinal endoscopy devices market is expected to reach $6.6 billion in 2017 and $11 billion in 2023.
Companies like Biosense Webster (part of Johnson&Johnson), Pixcell Medical and RealView Imaging are developing new imaging technologies that will enable earlier and more effective treatment of a whole range of diseases.
Personalizing treatment for different types of cancer makes sense medically, but it requires specialized clinical research. CureWize is making that happen for treatment of cancers common in children, adolescents and young adults.
ASI develops computer-aided systems for use in diagnostics by pathology, cytogenetic and research laboratories. They provide labs with accurate, repeatable and standardized analysis of karyotyping, FISH, CISH, quantitative IHC, as well as spectral imaging for research applications.
Biosense Webster, a Johnson & Johnson company, specializes in the diagnosis and treatment of cardiac arrhythmias (abnormal electrical activity in the heart). Biosense Webster (Israel), Ltd. Is the Technology Center for R&D and Manufacturing for systems worldwide.
A global leader in its field, Biosense, Inc. began as a start-up in Haifa, Israel, with Dr. Shlomo Ben-Haim’s development of a 3-D cardiac mapping and navigation technology that provided new levels of insight, precision, and safety in the diagnosis and treatment of cardiac arrhythmias. At the same time, Webster Laboratories was founded by pioneer inventor Will Webster, whose advanced catheter designs were based on the practical needs and demands of physicians. In 1998, Biosense joined Webster Laboratories to form Biosense Webster.
2012 marked the fifteenth anniversary of the acquisition of Biosense Webster by Johnson & Johnson. Biosense Webster continues to be one of the fastest growing businesses in Johnson & Johnson and, in fact, has grown more than 20-fold since the acquisition. As the world’s leading cardiac electrophysiology company, Biosense Webster currently has more than 2000 employees worldwide, with above $1 billion in annual sales.
The CARTO® 3 System has given electrophysiologists access to 3-D, real-time, color-coded views into the heart’s electrical activity, allowing diagnosis and treat-ment with increasing precision. The ThermoCool® SmartTouch™ Contact Force Sensing Catheter provides electrophysiologists with the ability to sense the amount and force of contact. ThermoCool® SF Catheter with Surround Flow Technology provides uniform cooling during ablation procedures. Biosense Webster has also developed an image integration solution for electrophysiology labs around the world. This solution integrates real-time x-ray images, from Siemens Healthcare, GE Healthcare and Philips Healthcare X-Ray systems, into the CARTO® 3 System.
The diagnosis of Parkinson's is mainly based on patients' medical history and clinical examination. In some cases Parkinson's disease can be difficult to diagnose with early signs and symptoms being dismissed as the effects of normal aging.
BioShai is developing PDx, a simple blood test for the early diagnosis of Parkinson’s disease. The blood test can be combined with other clinical data to provide a more complete diagnosis to help physicians decide on the best course of treatment.
PDx is based on the measurement of the level of expression of a set of genes. Gene expression is a dynamic process affected by stress, diet, and health leading to dramatic changes in the amount of messenger RNA molecules and protein in the human body over the course of our lives.
Expected to be on the market in 2017.
The first mobile health tools that BrainMARC has developed, based on its platform technology, are: a Brain Engagement Monitor, which measures attention-related performance biomarkers; and a Comfort Monitor, which measures affect-related biomarkers. In both cases the BrainMARC software works in conjunction with a simple, off-the-shelf, 2-electrode EEG headset.
The BEM uses the Brain Engagement and Focus Events indices to provide real-time feedback regarding effectiveness of treatment-whether pharmaceutical, electromagnetic, behavioral or other (e.g., lifestyle modification) - for a wide variety of dysfunctions such as ADHD, migraine, anxiety disorders, depression, bipolar disorder, schizophrenia and dementia. It can also provide real-time feedback on attention recruitment during activities of daily living (ADL) rehabilitation, thus helping patients to more effectively restore their day-to-day functionality.
The CM uses the Comfort and Comfort Tendency indices to provide real-time feedback regarding levels of stress, interest/memorization and/or enjoyment. It can be used to assess the effectiveness of stress reduction treatments for dysfunctions such as anxiety and migraine, as well as to evaluate viewer responses to media clips.
BrainMARC has developed a breakthrough mobile health platform for monitoring mental activity. Its easy-to-use tool derives proven and robust biomarkers from EEG sampled via two (dry) electrodes only.
BrainMARC’s biomarkers are applicable to a wide spectrum of neuropsychiatric syndromes where they can enhance therapeutic protocols, predict clinical dynamics, and promote general wellness – They are also suitable for non-medical and research applications.
CMT Medical Technologies is a leading provider of advanced digital X-ray imaging systems for medical diagnosis. CMT provides high resolution digital imaging solutions for General Radiography, R&F rooms and Angiography special procedures suites. CMT products available in multiple configurations and as a subsystems for OEMs to incorporate into their own newly manufactured X-ray rooms.
The first product of the company is 3D intraoral camera which has in addition curing light, illumination for early detection of dental caries and oral cancer. This product will also have the ability to make 3D intraoral scans for orthodontic applications.
Curewize Health is a clinical research and commercialization company aiming to advance the personalized treatment of cancers common to children, adolescents and young adults. Its lead product family is ProALLTM, which are microRNA (miRNA) based predictive tests for the early prognosis and monitoring of Acute Lymphoblastic Leukemia (ALL) patients. ProALLTM assays will change the complicated and lengthy process of deciding how to treat a leukemia patient to a clear and simple process.
Since pioneering the field of capsule endoscopy in 2001, Medtronic (formally Given Imaging) has become a world leader in GI medical devices, offering health care providers a range of innovative options for visualizing, diagnosing and monitoring the digestive system. The company's technology is the PillCam™ Platform, featuring the PillCam™ video capsule, a disposable, miniature video camera contained in a capsule, which is ingested by the patient, a sensor array, data recorder and RAPID™ software.
Medtronic has four commercially available capsules: the PillCam™ SB video capsule to visualize the entire small intestine, the PillCam™ COLON video capsule to visualize the colon, the PillCam™ UGI video capsule to visualize the upper GI tract, including the esophagus, stomach and first part of the small intestine and the PillCam™ Patency capsule to assess functional patency in the GI tract.
PixCell Medical Technologies develops, produces, and markets portable medical diagnostic products for point of care testing. PixCell's products are based on its innovative Viscoleastic Focusing (VEF) technology and single use cartridges that enable rapid, accurate and simple blood sampling and analysis. Results are displayed within minutes in an easily readable format. PixCell's mission is to make tests currently restricted to the laboratory more accessible, easy to use and affordable.
RealView Imaging Ltd is introducing the world’s first 3D holographic display and interface system, initially for medical imaging applications. The company’s proprietary technology projects hyper-realistic, dynamic 3D holographic images “floating in the air” without the need for any type of eyewear or a conventional 2D screen. The projected 3D volumes appear in free space, allowing the user to literally touch and interact precisely within the image, presenting a unique and proprietary breakthrough in digital holography and real-time 3D interaction capabilities.
Sorek Medical Systems Ltd. is an R&D company focused on developing high-tech medical subsystems, including electronic interfaces, computer algorithms and mechanical manipulators.
The company is using advanced digital and analog technology such as FPGA, microcontrollers, high level analog interfaces and front ends, high accuracy CNC and 3D printing.
The main line of development is MRI add-ons, which makes the company an expert in electromagnetic subsystems.
Sorek is responsible for small scale manufacturing and installation of some of its products for clinical and investigational use.
As the subsidiary of Robin Medical Inc., the company developed the EndoScout® system enables tracking of the location and orientation of miniature sensors during an MRI scan. The tracking is based on the native gradient fields of the MRI scanner, thus there is no need to register the tracking system to the scanner before each use. The system can be easily installed and used on any scanner, with no need to modify the scanner or its mode of operation and with no electromagnetic interference.
As an expert in electromagnetic navigation, the company developed for a location and orientation system for gastrointestinal navigation system using the Given Imaging capsule.
Carmel Diagnostics is an Israeli privately owned healthcare company that develops clinical applications of its proprietary Thermochemiluminescence technology platform. The technology enables assessment of oxidative stress in body fluids and prediction of clinical problems linked to levels of oxidative stress.
TCL Analyzer™, a diagnostic medical device based on TCL technology, has been constructed and validated both in laboratory and pre-clinical studies.
Carmel Diagnostics focuses its activity on two major applications: prediction of Congestive Heart Failure (CHF) condition, and selection of the most promising embryo for implantation duringIn-Vitro Fertilization (IVF) procedures. Proof of concept for both applications has been demonstrated in pre-clinical studies.