Yokneam is located at the junction of the country’s major highways that connect all of Israel with both Tel-Aviv and Jerusalem. In 2016, the train line between Haifa and the Jordanian border is scheduled to open in 2016 with the Kfar Yehoshua train station only five minutes from Yokneam's high tech parks.

Two major universities (Technion and University of Haifa) and the Neve Ya'ar agricultural research institute are all within a 20 minute radius.